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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2AK4
All Species:
18.79
Human Site:
S1569
Identified Species:
41.33
UniProt:
Q9P2K8
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9P2K8
NP_001013725.2
1649
186838
S1569
L
A
N
L
H
Q
K
S
S
E
I
E
I
L
A
Chimpanzee
Pan troglodytes
XP_001140245
1649
186793
S1569
L
A
N
L
H
Q
K
S
S
E
I
E
I
L
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_535431
1633
184740
A1546
I
A
P
E
K
L
S
A
S
T
R
R
R
Y
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9QZ05
1648
186468
S1568
L
A
N
L
H
Q
K
S
S
E
I
E
I
L
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518247
1608
180821
S1528
L
A
N
L
H
Q
K
S
S
E
I
E
I
L
A
Chicken
Gallus gallus
XP_421203
1656
188583
T1575
V
S
G
L
Q
Q
K
T
S
E
I
E
I
L
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667149
1483
168725
Y1404
S
A
S
S
R
R
R
Y
E
T
Q
I
Q
T
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120977
1130
130476
E1051
I
S
H
K
I
P
I
E
I
F
A
K
W
V
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785160
1605
181469
E1526
Q
M
K
L
N
K
V
E
L
T
E
Q
S
P
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LX30
1241
140303
K1162
E
L
W
E
K
S
I
K
A
E
F
V
P
T
P
Baker's Yeast
Sacchar. cerevisiae
P15442
1659
190175
D1564
R
E
K
W
V
Y
E
D
A
A
R
N
S
S
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
N.A.
89.7
N.A.
90.5
N.A.
N.A.
74.7
72.3
N.A.
52.6
N.A.
N.A.
27.9
N.A.
40.4
Protein Similarity:
100
99.9
N.A.
94.3
N.A.
94.9
N.A.
N.A.
84.4
84.5
N.A.
67.4
N.A.
N.A.
44
N.A.
59.4
P-Site Identity:
100
100
N.A.
13.3
N.A.
100
N.A.
N.A.
100
66.6
N.A.
6.6
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
100
100
N.A.
26.6
N.A.
100
N.A.
N.A.
100
86.6
N.A.
26.6
N.A.
N.A.
33.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
26.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.7
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
55
0
0
0
0
0
10
19
10
10
0
0
0
46
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
10
10
0
19
0
0
10
19
10
55
10
46
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
10
10
0
0
0
0
% F
% Gly:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
10
0
37
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
19
0
0
0
10
0
19
0
10
0
46
10
46
0
0
% I
% Lys:
0
0
19
10
19
10
46
10
0
0
0
10
0
0
0
% K
% Leu:
37
10
0
55
0
10
0
0
10
0
0
0
0
46
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
37
0
10
0
0
0
0
0
0
10
0
0
10
% N
% Pro:
0
0
10
0
0
10
0
0
0
0
0
0
10
10
10
% P
% Gln:
10
0
0
0
10
46
0
0
0
0
10
10
10
0
10
% Q
% Arg:
10
0
0
0
10
10
10
0
0
0
19
10
10
0
10
% R
% Ser:
10
19
10
10
0
10
10
37
55
0
0
0
19
10
0
% S
% Thr:
0
0
0
0
0
0
0
10
0
28
0
0
0
19
0
% T
% Val:
10
0
0
0
10
0
10
0
0
0
0
10
0
10
0
% V
% Trp:
0
0
10
10
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
10
0
10
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _